I have no personal experience with the safr and a medium amount with the safc. The safc is set at 0, just stock fuel maps when you install it. It's very easy to use and it obviously works since at least 3/4 of the dsms out there run it and get good times. Now as for the SAFR I know one person that has used it. Lowell Foo, he tunes professionally. He has used just about every engine management system out there <he runs a motec M48pro on his 1G AWD, flat twelves on pump gas with a frank 3!?>. He absolutely HATED the SAFR. I can't remember his exact reasoning, this was about 7 months ago, but in a nutshell it just wouldn't do what he wanted it too.
fuel pressure regulators: yes the sx, paxton, aeromotive, and aem will all allow you to run whatever you want. There is a vfaq on the install. DO NOT get a sx or paxton, they both fall apart over time. The aeromotive is what most people are heading towards now...