Basicaly you don't need to worry about LO settings as long as you are in the ballpark figure of what the ECU of the car would see with stock injectors. What I mean is, if you use 550 cc injectors (18% more than stock) then you would set your LO settings to around -18% to take away that extra fuel those injectors are dishing out (this varies depending on your fuel pump also). The reason this is possible (and can be loosly interpreted this way) is because under 40% throttle position, the ECU is over-riding the s-afc and making its own adjustments anyway. Let me say that again: Under %40 throttle position, the ECU is making its own adjustments as it would normally for fuel economy, gas mileage, responsiveness, etc etc. If you are not in the ballpark of what the computer itself can add or take away fuel, then you will have problems because the ECU can only do so much richer or leaner to compensate for less than adequate LO settings. THis is easy to see on a datalogger as I have seen. My short term fuel trims jump up and down + or - 5% or so to compensate for normal driving, but they ALWAYS find their way back to 0% on the short term fuel trims.
Don't quote me on this and in no way goto your settings and adjust things based on what I have said. Every car is different and different mods will definately make for different Lo settings. My settings are actually not as I have stated above but my HI settings do follow that scenario (my 660cc injectors are 32% larger than stock and my HI settings are around -32% but my Lo settings are richer around -25%) What works for me won't work for you necessarily, it is just a basic way to get things working before you find your own sweet spot. I tune with a datalogger for Timing and use the EGT to confirm safe temps.
Im sure lots of people have different opinions and I would like to hear some because sometimes I wonder why my stuff is alot different than most. Probably because of the Webcams. Anyone want to add? (sorry for the long reply and I hope it offers some useful info)